|
Equipe 4 : Micro-organismes et
physiopathologie intestinale ERL U1057 INSERM
Directeur de l’unité :Germain
TRUGNAN (PUPH1)
|
La
thématique centrale de l’équipe se concentre sur les
modalités et les conséquences du dialogue entre
microorganismes et cellules épithéliales intestinales
humaines. Nous développons une démarche intégrative et
translationnelle allant de la biologie fondamentale à la
clinique humaine. Nous disposons pour cela d’un large
éventail d’expertises reconnues que nous mettons au service
d’un projet resserré : biologie cellulaire, imagerie
cellulaire, lipidomique et biophysique des membranes,
protéomique, physiopathologie digestive, microbiologie,
virologie cellulaire et moléculaire, gastroentérologie
clinique. Deux aspects particuliers de ce dialogue ont été
choisis pour leurs intérêts fondamentaux et leurs retombées
cliniques potentielles. Nous nous intéressons d’une part à des
microorganismes non pathogènes, les bactéries du microbiote
intestinal, aux mécanismes de leur dialogue avec les cellules
épithéliales intestinales et aux conséquences d’une dysbiose
dans le contexte des maladies inflammatoires chroniques de
l’intestin (MICI). Nous nous intéressons d’autre part à des
microorganismes pathogènes, les rotavirus, au rôle joué par
l’épithélium intestinal dans leur assemblage et leur
propagation et surtout aux applications de ces connaissances
pour le développement de stratégies thérapeutiques antivirales
innovantes. Ces deux axes sont intriqués et s’appuient sur la
nécessité commune de disposer de connaissances et d’outils
performants pour la biologie cellulaire, la biochimie et la
biophysique des cellules épithéliales intestinales.
L’évolution des travaux
menés depuis plusieurs années nous ont conduits à
développer des recherches interdisciplinaires aux interfaces
entre la chimie, la physique, la biologie et la médecine. Nous
avons notamment engagé des collaborations approfondies avec
l’UMR 7203 que nous avons rejoint dernièrement après une
évaluation A+ de l’AERES pour développer des projets
interdisciplinaires
|
-
Thématique : procaryotes et
inflammation intestinale
-
Thématique : Interaction virus -
cellules intestinales
Publications et contrats
ANR
MI2 2010 IMPRO-Fprau : Mécanismes Intégrés de
l'Inflammation : Analyse des effets immuno-modulateurs des
peptides issus d'une protéine spécifique de Faecalibacterium
prausnitzii, une bactérie commensale impliquée dans la maladie
de Crohn
Publications
|
2012 |
Inflammatory bowel disease
therapies and cancer risk where are we and where are we going?
|
Beaugerie L.
|
Gut. |
2012 Jan 12.
|
|
2012 |
Development of the first disability index for inflammatory
bowel disease based on the international classification of
functioning, disability and health. |
Peyrin-Biroulet L, Cieza A, Sandborn WJ, Coenen M, Chowers
Y, Hibi T, Kostanjsek N, Stucki G, Colombel JF; International
Programme to Develop New Indexes for Crohn's Disease (IPNIC)
group. |
Gut. |
2012 Feb;61(2) 241-7.
|
|
2012 |
High plasma level of nucleocapsid-free envelope
glycoprotein-positive lipoproteins in hepatitis C patients.
|
Scholtes C, Ramiere C, Rainteau D, Perrin-Cocon L, Wolf C,
Humbert L, Carreras M, Guironnet-Paquet A, Zoulim F,
Bartenschlager R, Lotteau V, André P, Diaz O. |
Hepatology.
|
2012 Jan 30.. 10.1002/hep.25628
|
|
2012 |
Excess primary intestinal
lymphoproliferative disorders in patients with inflammatory
bowel disease. |
Sokol H, Beaugerie L, Maynadié M, Laharie D, Dupas JL,
Flourié B, Lerebours E, Peyrin-Biroulet L, Allez M, Simon T,
Carrat F, Brousse N; for the CESAME Study Group. |
Inflamm Bowel Dis.
|
2012 Jan 23. doi. 10.1002/ibd.22889
|
|
2012 |
Colorectal neoplasia in PSC-IBD
patients are times changing? |
Sokol H, Chazouilleres O.
|
Liver Int
|
2012 Feb;32(2) 175-6. doi
10.1111/j.1478-3231.
2011.02671.x. |
|
2012 |
Glycan-modifying bacteria-derived soluble factors from
Bacteroides thetaiotaomicron and Lactobacillus casei inhibit
rotavirus infection in human intestinal cells. |
Varyukhina S, Freitas M, Bardin S,
Robillard E, Tavan E, Sapin C, Grill JP, Trugnan G.
|
Microbes Infect.
|
2012 Mar;14(3) 273-8.
|
|
2011 |
Diagnostic Profiles Determined by
the c.a.r.t Procedure ibd Patients and Fatigue.
|
Banovic I, Gilibert D, Jebrane A,
Cosnes J. |
J Health Psychol
|
2011 |
|
2011 |
Air mass pushing the liver.,
|
Barret M., Coriat R., Beaugerie L.,
Sokol H., |
Digestive and Liver Disease
, |
2011 Dec;43(12) 1025.
|
|
2011 |
Pregnancy outcome in patients with inflammatory bowel
disease treated with thiopurines: cohort from the CESAME
Study., |
Coelho J., Beaugerie L., Colombel J. F., Hébuterne X.,
Lerebours E., Lémann M., Baumer P., Cosnes J., Bourreille A.,
Gendre J. P., Seksik P., Blain A., Metman E. H., Nisard A.,
Cadiot G., Veyrac M., Coffin B., Dray X., Carrat F., Marteau
P.,, |
Gut ,
|
2011, 60 2 198-203
|
|
2011 |
[Complications of celiac disease.].
|
Cosnes J, Nion-Larmurier I.
|
Pathol Biol (Paris).
|
2011 May 26.
|
|
2011 |
Epidemiology and natural history of
inflammatory bowel diseases., |
Cosnes J., Gower-Rousseau C.,
Seksik P., Cortot A., |
Gastroenterology ,
|
2011, 140 6 1785-94
|
|
2011 |
Trade-off between bile resistance and nutritional
competence drives Escherichia coli diversification in the
mouse gut. |
De Paepe M, Gaboriau-Routhiau V,
Rainteau D, Rakotobe S, Taddei F, Cerf-Bensussan N.
|
PLoS Genet.
|
2011 Jun;7(6) e1002107.
|
|
2011 |
Immediate neuroendocrine signaling after partial
hepatectomy through acute portal hyperpressure and
cholestasis. |
Doignon I, Julien B, Serriere-Lanneau V, Garcin I, Alonso
G, Nicou A, Monnet F, Gigou M, Humbert L, Rainteau D, Azoulay
D, Castaing D, Gillon MC, Samuel D, Duclos-Vallée JC,
Tordjmann T. |
J Hepatol.
|
2011 Mar;54(3) 481-8.
|
|
2011 |
C-reactive protein and transesophageal echocardiographic
markers of thromboembolism in patients with atrial
fibrillation., |
Ederhy S., Di Angelantonio E., Dufaitre G., Meuleman C.,
Masliah J., Boyer-Chatenet L., Boccara F., Cohen A., |
Int J Cardiol.
|
2011 Mar 12.
|
|
2011 |
Proof of principle for transfusion
of in vitro-generated red blood cells.
|
Giarratana MC, Rouard H, Dumont A, Kiger L, Safeukui I, Le
Pennec PY, François S, Trugnan G, Peyrard T, Marie T, Jolly
S, Hebert N, Mazurier C, Mario N, Harmand L, Lapillonne H,
Devaux JY, Douay L. |
Blood. |
2011 Nov 10;118(19) 5071-9.
|
|
2011 |
A comparison of small monetary
incentives to convert survey non-respondents a randomized
control trial. |
Griffin JM, Simon AB, Hulbert E,
Stevenson J, Grill JP, Noorbaloochi S, Partin MR.
|
BMC Med Res Methodol.
|
2011 May 26;11 PAGE ?
|
|
2011 |
Regulation of colon cancer cell
proliferation and migration by MD-2 activity.
|
Grondin V, Seksik P, Dumont S,
Thomas G, Trugnan G, Fléjou JF, Masliah J, Wendum D, Bachelet
M. |
Innate Immun.
|
2011 Aug;17(4) 414-22.
|
|
2011 |
Successive treatment with
cyclosporine and infliximab in steroid-refractory ulcerative
colitis., |
Leblanc S., Allez M., Seksik P., Flourié B., Peeters H.,
Dupas J.L., Bouguen G., Peyrin-Biroulet L., Duclos B.,
Bourreille A., Dewit O., Bouhnik Y., Michetti P., Chaussade
S., Saussure P., Mary J.Y., Colombel J.F., Lémann M.,, |
Am J Gastroenterol.,
|
2011, 106 4 771-7
|
|
2011 |
Mononeuropathy multiplex associated with acute parvovirus
B19 infection: characteristics, treatment and outcome.,
|
Lenglet T., Haroche J., Schnuriger A., Maisonobe T., Viala
K., Michel Y., Chelbi F., Grabli D., Seror P., Garbarg-Chenon
A., Amoura Z., Bouche P., |
J Neurology ,
|
2011, 258 7 1321-6
|
|
2011 |
Protoporphyrin retention in hepatocytes and Kupffer cells
prevents sclerosing cholangitis in erythropoietic
protoporphyria mouse model. |
Lyoumi S, Abitbol M, Rainteau D, Karim Z, Bernex F, Oustric
V, Millot S, Lettéron P, Heming N, Guillmot L, Montagutelli X,
Berdeaux G, Gouya L, Poupon R, Deybach JC, Beaumont C, Puy H.
|
Gastroenterology.
|
2011 Oct;141(4) 1509-19, 1519.e1-3.
|
|
2011 |
[Chronic diarrhea which diagnostic
approach?]. |
Nion-Larmurier I, Cosnes J.
|
Rev Prat.
|
2011 Nov;61(9) 1278.
|
|
2011 |
Monitoring epidemic viral respiratory infections using
one-step real-time triplex RT-PCR targeting influenza A and B
viruses and respiratory syncytial virus. |
Papillard-Marechal S, Enouf V, Schnuriger A, Vabret A,
Macheras E, Rameix-Welti MA, Page B, Freymuth F, van der Werf
S, Garbarg-Chenon A, Chevallier B, Gaillard JL, Gault E.
|
J Med Virol.
|
2011 Apr;83(4) 695-701. doi
10.1002/jmv.22006. |
|
2011 |
[Impact of Rotavirus gastroenteritis requiring
hospitalization or presenting to emergency room among children
less than 5years in France.]. |
Parez N, Mory O, Pozzetto B,
Garbag-Chenon A, Pillet S, Texier N, Téhard B.
|
Pathol Biol (Paris).
|
2011 Jul 30.
|
|
2011 |
Development of the Crohn's disease
digestive damage score, the Lémann score.,
|
Pariente B., Cosnes J., Danese S., Sandborn W. J., Lewin
M., Fletcher J. G., Chowers Y., D'Haens G., Feagan B. G., Hibi
T., Hommes D. W., Irvine E. J., Kamm M. A., Loftus E. V.,
Louis E., Michetti P., Munkholm P., Oresland T., Panés J.,
Peyrin-Biroulet L., Reinisch W., Sands B. E., Schoelmerich J.,
Schreiber S., Tilg H., Travis S., Van Assche G., Vecchi M.,
Mary J.-Y., Colombel J.-F., Lémann M., |
Inflamm Bowel Dis
|
2011, 17 6 1415-22
|
|
2011 |
Increased Risk for Nonmelanoma Skin Cancers in Patients Who
Receive Thiopurines for Inflammatory Bowel Disease., |
Peyrin-Biroulet L., Khosrotehrani K., Carrat F., Bouvier
A.-M., Chevaux J.-B., Simon T., Carbonnel F., Colombel J.-F.,
Dupas J.-L., Godeberge P., Hugot J.-P., Lémann M., Nahon S.,
Sabaté J.-M., Tucat G., Beaugerie L.,, |
Gastroenterology ,
|
2011 Nov;141(5):1621-2
|
|
2011 |
Anti-inflammatory properties of
dairy lactobacilli. |
Santos Rocha C, Lakhdari O, Blottiere HM, Blugeon S, Sokol
H, Bermu'dez-Humara'n LG, Azevedo V, Miyoshi A, Doré J,
Langella P, Maguin E, van de Guchte M. |
Inflamm Bowel Dis.
|
2011 Aug 11. doi 10.1002/ibd.21834.
|
|
2011 |
*page Anti-inflammatory properties
of dairy lactobacilli., |
Santos Rocha C., Lakhdari O., Blottière H. M., Blugeon S.,
Sokol H., Bermu'Dez-Humara'N L. G., Azevedo V., Miyoshi A.,
Doré J., Langella P., Maguin E., Van De Guchte M., |
Inflamm Bowel Dis,
|
2011 Aug 11. doi: 10.1002/ibd.21834
|
|
2011 |
Incidence of nodular regenerative hyperplasia in
inflammatory bowel disease patients treated with
azathioprine., |
Seksik P., Mary J.-Y., Beaugerie L., Lémann M., Colombel
J.-F., Vernier-Massouille G., Cosnes J.,, |
Inflamm Bowel Dis
|
2011, 17 2 565-72
|
|
2011 |
Limits of sequencing and phylogenetic analysis to assess
B19V transmission by single-donor blood component., |
Servant-Delmas A., Laperche S., Mercier M., Michel Y.,
Garbarg-Chenon A., Boyeldieu D., Pelissier E., Lefrère J.-J.,,
|
Vox sanguinis |
2011, 100 2 254-5
|
|
2011 |
Arsenic trioxide reduces 2,4,6-trinitrobenzene sulfonic
acid-induced murine colitis via nuclear factor-{ kappa} B
down-regulation and caspase-3 activation., |
Singer M., Trugnan G., Chelbi-Alix
M. K., |
Innate Immun ,
|
2011 Aug;17(4) 365-74.
|
|
2011 |
Rotavirus rearranged genomic RNA segments are
preferentially packaged into viruses despite not conferring
selective growth advantage to viruses. |
Troupin C, Schnuriger A, Duponchel
S, Deback C, Schnepf N, Dehee A, Garbarg-Chenon A.
|
PLoS One.
|
2011; 6(5) e20080.
|
|
2011 |
Food-starch granulomatous peritonitis in a patient with
ileal Crohn's disease a rare aetiology of peritoneal giant
cell granulomas with caseation necrosis mimicking peritoneal
tuberculosis. |
Varinot J, Cosnes J, Chafai N,
Bennis M, Fléjou JF, Svrcek M. |
Int J Colorectal Dis.
|
2011 Oct 18.
|
|
2011 |
Low prevalence of colonoscopic surveillance of inflammatory
bowel disease patients with longstanding extensive colitis: a
clinical practice survey nested in the CESAME cohort., |
Vienne A., Simon T., Cosnes J., Baudry C., Bouhnik Y.,
Soulé J.C., Chaussade S., Marteau P., Jian R., Delchier J.-C.,
Coffin B., Admane H., Carrat F., Drouet E., Beaugerie L.,
|
Alimentary Pharmacology
and Therapeutics ,
|
2011, 34 2 188-95
|
|
2010 |
Lipid domain separation, bilayer thickening and pearling
induced by the cell penetrating peptide penetratin., |
Lamazière A., Maniti O., Wolf C.,
Lambert O., Chassaing G., Trugnan G., Ayala-Sanmartin J.,
|
BBA - Biochimica et Biophysica Acta |
2010, 1798 (12) 2223-30
|
|
2010 |
Distinct behaviour of the homeodomain derived cell
penetrating peptide penetratin in interaction with different
phospholipids., |
Maniti O., Alves I., Trugnan G.,
Ayala-Sanmartin J., |
PLoS ONE ,
|
2010, 5 (12) e15819
|
|
2010 |
[Impact of childhood immunization
programs in 20th century France]. |
Ajana F, Alain S, Angelin-Duclos C, Aumaitre H, Bregere P,
Launay O, Parez N, Rogeaux O, Soubeyrand B, Strady C,
Weil-Olivier C. Group Avancées Vaccinales, Gaillat J. |
Rev Prat.
|
2010 Oct 20;60(8) 1044-8.
|
|
2010 |
Crohn's disease and fatigue: constancy and co-variations of
activity of the disease, depression, anxiety and subjective
quality of life., |
Banovic I., Gilibert D., Cosnes
J.,, |
Psychology, Health & Medicine |
2010, 15 4 394-405
|
|
2010 |
Liver dysfunction in patients with
IBD under immunosuppressive treatment: do we need to fear?,
|
Beaugerie L., Gerbes A. L.,
|
Gut ,
|
2010, 59 10 1310-1
|
|
2010 |
Appendicitis, not appendectomy, is protective against
ulcerative colitis, both in the general population and
first-degree relatives of patients with IBD., |
Beaugerie L., Sokol H.,
|
Inflamm Bowel Dis
|
2010, 16 2 356-7
|
|
2010 |
Risk factors for neoplasia in
inflammatory bowel disease patients with pancolitis.,
|
Bergeron V., Vienne A., Sokol H., Seksik P., Nion-Larmurier
I., Ruskone-Fourmestraux A., Svrcek M., Beaugerie L., Cosnes
J., |
Am J Gastroenterol.
|
2010, 105 11 2405-11
|
|
2010 |
Rotaviruses associate with cellular lipid droplet
components to replicate in viroplasms, and compounds
disrupting or blocking lipid droplets inhibit viroplasm
formation and viral replication., |
Cheung W., Gill M., Esposito A., Kaminski C. F., Courousse
N., Chwetzoff S., Trugnan G., Keshavan N., Lever A.,
Desselberger U., |
J Virol ,
|
2010, 84 13 6782-98
|
|
2010 |
Acute cryptosporidiosis as a cause of sudden recurrence of
digestive symptoms in patients with Crohn's disease., |
Colussi O., Rouen A., Seksik P.,
Cosnes J., Beaugerie L., Sokol H., |
J Crohns Colitis ,
|
2010, 4 6 669-70
|
|
2010 |
Rotavirus-like particles a novel
nanocarrier for the gut. |
Cortes-Perez NG, Sapin C, Jaffrelo L, Daou S, Grill JP,
Langella P, Seksik P, Beaugerie L, Chwetzoff S, Trugnan G.
|
J Biomed Biotechnol.
|
2010; 2010:317545
|
|
2010 |
Smoking, physical activity,
nutrition and lifestyle: environmental factors and their
impact on IBD., |
Cosnes J.,
|
Digestive Diseases |
2010, 28 3 411-7
|
|
2010 |
Human intestinal microbiota gene risk factors for
antibiotic-associated diarrhea: perspectives for prevention.
Risk factors for antibiotic-associated diarrhea., |
De La Cochetière M. F., Montassier E., Hardouin J.-B.,
Carton T., Le Vacon F., Durand T., Lalande V., Petit J.-C.,
Potel G., Beaugerie L., |
Microb Ecol.,
|
2010, 59 4 830-7
|
|
2010 |
Characteristics and clinical course of primary sclerosing
cholangitis in France a prospective cohort study. |
Garioud A, Seksik P, Chrétien Y,
Corphechot C, Poupon R, Poupon RE, Chazouilleres O.
|
Eur J Gastroenterol Hepatol.
|
2010 Jul;22(7) 842-7.
|
|
2010 |
Unilateral carotid granulomatous
arteritis and Crohn's disease., |
Gobron C., Kaci R., Sokol H.,
Vahedi K., Lejoyeux P., Guillaud C., Wechsler B., Gray F.,
Bousser M.-G.,, |
Revue neurologique |
2010, 166 5 542-6
|
|
2010 |
Surveillance to estimate the burden of rotavirus
gastroenteritis in children aged less than 3 years attending
day care centers in Paris, France., |
Grimprel E., Garbarg-Chenon A.,
PirÁon J.-Y., Curran D., Soriano-GabarrÛ M., Meyer N.,
|
Human Vaccines ,
|
2010, 6 5 399-406
|
|
2010 |
Regulation of colon cancer cell
proliferation and migration by MD-2 activity.,
|
Grondin V., Seksik P., Dumont S., Thomas G., Trugnan G.,
Fléjou J.-F., Masliah J., Wendum D., Bachelet M., |
Innate Immun ,
|
2010, epub ahead of print *page
|
|
2010 |
The enteropathy associated with common variable
immunodeficiency: the delineated frontiers with celiac
disease., |
Malamut G., Verkarre V., Suarez F., Viallard J.-F., Lascaux
A.-S., Cosnes J., Bouhnik Y., Lambotte O., Béchade D., Ziol
M., Lavergne A., Hermine O., Cerf-Bensussan N., Cellier C.,
|
Am J Gastroenterol.,
|
2010, 105 10 2262-75
|
|
2010 |
Natural history of Crohn's disease:
comparison between childhood- and adult-onset disease.,
|
Pigneur B., Seksik P., Viola S.,
Viala J., Beaugerie L., Girardet J.-P., Ruemmele F. M., Cosnes
J., |
Inflamm Bowel Dis,
|
2010, 16 6 953-61
|
|
2010 |
Severe skin lesions cause patients with inflammatory bowel
disease to discontinue anti-tumor necrosis factor therapy.,
|
Rahier J.-F., Buche S., Peyrin-Biroulet L., Bouhnik Y.,
Duclos B., Louis E., Papay P., Allez M., Cosnes J., Cortot A.,
Laharie D., Reimund J.-M., Lémann M., Delaporte E., Colombel
J.-F.,, |
Clinical Gastroenterology and Hepatology
, |
2010, 8 12 1048-55
|
|
2010 |
[Gut microbiota and IBD].,
|
Seksik P.,
|
Gastroenterol Clin Biol.
|
2010, 34 Suppl 1 S44-51
|
|
2010 |
Sera from patients with Crohn's disease break bacterial
lipopolysaccharide tolerance of human intestinal epithelial
cells via MD-2 activity., |
Seksik P., Sokol H., Grondin V., Adrie C., Duboc H.,
Pigneur B., Thomas G., Beaugerie L., Trugnan G., Masliah J.,
Bachelet M.,, |
Innate Immun |
2010, 16 6 381-90
|
|
2010 |
Current smoking, not duration of remission, delays Crohn's
disease relapse following azathioprine withdrawal. |
Sokol H, Seksik P, Nion-Larmurier
I, Vienne A, Beaugerie L, Cosnes J. |
Inflamm Bowel Dis.
|
2010 Mar;16(3) 362-3.
|
|
2010 |
Misleading statement in trial on
false-positive results in lung cancer screening.,
|
Sokol H. N.,
|
Annals of internal medicine
, |
2010, 153 3 210; author reply 210
|
|
2010 |
Body mass index and disease activity at treatment
initiation: potential new predictors of response to
azathioprine therapy in IBD., |
Sokol H., Beaugerie L.,
|
Inflamm Bowel Dis
|
2010, 16 4 714-5
|
|
2010 |
[Acute diarrhea in the adult].,
|
Sokol H., Beaugerie L.,
|
Rev pra |
2010, 60 3 413-8
|
|
2010 |
Gastrointestinal involvement and
manifestations in systemic mastocytosis.,
|
Sokol H., Georgin-Lavialle S., Grandpeix-Guyodo C., Canioni
D., Barete S., Dubreuil P., Lortholary O., Beaugerie L.,
Hermine O., |
Inflamm Bowel Dis
|
2010, 16 7 1247-53
|
|
2010 |
The intestinal microbiota in
inflammatory bowel diseases: time to connect with the host.,
|
Sokol H., Seksik P.,
|
Current Opinion in Gastroenterology
, |
2010, 26 4 327-31
|
|
2010 |
Usefulness of co-treatment with immunomodulators in
patients with inflammatory bowel disease treated with
scheduled infliximab maintenance therapy., |
Sokol H., Seksik P., Carrat F.,
Nion-Larmurier I., Vienne A., Beaugerie L., Cosnes J.,
|
Gut ,
|
2010, 59 10 1363-8
|
|
2010 |
Current smoking, not duration of remission, delays Crohn's
disease relapse following azathioprine withdrawal., |
Sokol H., Seksik P., Nion-Larmurier
I., Vienne A., Beaugerie L., Cosnes J.,
|
Inflamm Bowel Dis
|
2010, 16 3 362-3
|
|
2010 |
Crypt abscess-associated microbiota
in inflammatory bowel disease and acute self-limited colitis.,
|
Sokol H., Vasquez N., Hoyeau-Idrissi N., Seksik P.,
Beaugerie L., Lavergne-Slove A., Pochart P., Marteau P.,
|
World J Gastroenterology ,
|
2010, 16 5 583-7
|
|
2010 |
Methylation tolerance due to an O6-methylguanine DNA
methyltransferase (MGMT) field defect in the colonic mucosa:
an initiating step in the development of mismatch
repair-deficient colorectal cancers., |
Svrcek M., Buhard O., Colas C., Coulet F., Dumont S.,
Massaoudi I., Lamri A., Hamelin R., Cosnes J., Oliveira C.,
Seruca R., Gaub M.-P., Legrain M., Collura A., Lascols O.,
Tiret E., Fléjou J.-F., Duval A., |
Gut ,
|
2010, 59 11 1516-26
|
|
2010 |
Rearranged genomic RNA segments
offer a new approach to the reverse genetics of rotaviruses.,
|
Troupin C., Dehée A., Schnuriger
A., Vende P., Poncet D., Garbarg-Chenon A.,
|
J Virol ,
|
2010, 84 13 6711-9
|
|
2010 |
The second European evidence-based Consensus on the
diagnosis and management of Crohn's disease: Definitions and
diagnosis., |
Van Assche G., Dignass A., Panes J., Beaugerie L.,
Karagiannis J., Allez M., Ochsenk¸hn T., Orchard T., Rogler
G., Louis E., Kupcinskas L., Mantzaris J. G., Travis S.,
Stange E.,, |
J Crohns Colitis ,
|
2010, 4 1 7-27
|
|
2010 |
Intragastric administration of a superoxide
dismutase-producing recombinant Lactobacillus casei BL23
strain attenuates DSS colitis in mice., |
Watterlot L., Rochat T., Sokol H., Cherbuy C., Bouloufa I.,
Lefèvre F., Gratadoux J.-J., Honvo-Hueto E., Chilmonczyk S.,
Blugeon S., Corthier G., Langella P., Berm˙dez-Humar·n L. G.,
|
International J Food Microbiology
, |
2010, 144 1 35-41
|
|
2009 |
Lipid reorganization induced by membrane-active peptides
probed using differential scanning calorimetry., |
Joanne P., Galanth C., Goasdoué N., Nicolas P., Sagan S.,
Lavielle S., Chassaing G., El Amri C., Alves I. D., |
BBA - Biochimica et Biophysica Acta
, |
2009, 1788 (9): 1772-81
|
|
2009 |
Tubular structures in heterogeneous
membranes induced by the cell penetrating peptide penetratin.,
|
Lamazière A., Chassaing G., Trugnan
G., Ayala-Sanmartin J., |
Commun Integr Biol ,
|
2009, 2: (3) 223-4
|
|
2009 |
Abnormal transbilayer distribution
of phospholipids in red blood cell membranes in
schizophrenia., |
Nuss P., Tessier C., Ferreri F., De
Hert M., Peuskens J., Trugnan G., Masliah J., Wolf C.,
|
Psychiatry Research |
2009, 169 (2): 91-6
|
|
2009 |
Basolateral internalization of GPI-anchored proteins occurs
via a clathrin-independent flotillin-dependent pathway in
polarized hepatic cells. |
Ait-Slimane T, Galmes R, Trugnan G,
Maurice M. |
Mol Biol Cell.
|
2009 Sep;20(17) 3792-800.
|
|
2009 |
Perception of improved state of health and subjective
quality of life in Crohn's disease patients treated with
Infliximab. |
Banovic I, Gilibert D, Cosnes J.
|
J Crohns Colitis.
|
2009 Feb;3(1) 25-31.
|
|
2009 |
Lymphoproliferative disorders in patients receiving
thiopurines for inflammatory bowel disease a prospective
observational cohort study. |
Beaugerie L, Brousse N, Bouvier AM, Colombel JF, Lémann M,
Cosnes J, Hébuterne X, Cortot A, Bouhnik Y, Gendre JP, Simon
T, Maynadié M, Hermine O, Faivre J, Carrat F; CESAME Study
Group. |
Lancet. |
2009 Nov 7;374(9701) 1617-25.
|
|
2009 |
Patients with drug-induced microscopic colitis should not
be included in controlled trials assessing the efficacy of
anti-inflammatory drugs in microscopic colitis. |
Beaugerie L, Pardi DS.
|
Gastroenterology.
|
2009 Oct;137(4) 1535-6.
|
|
2009 |
Noncolorectal malignancies in
inflammatory bowel disease: more than meets the eye.,
|
Beaugerie L., Sokol H., Seksik P
|
Digestive Diseases ,
|
2009, 27 3 375-81
|
|
2009 |
Cyclosporine treatment of
steroid-refractory ulcerative colitis during pregnancy.
|
Branche J, Cortot A, Bourreille A, Coffin B, de Vos M, de
Saussure P, Seksik P, Marteau P, Lemann M, Colombel JF.
|
Inflamm Bowel Dis.
|
2009 Jul;15(7) 1044-8.
|
|
2009 |
Environmental risk factors in
Crohn's disease and ulcerative colitis an update.
|
Carbonnel F, Jantchou P, Monnet E,
Cosnes J. |
Gastroenterol Clin Biol.
|
2009 Jun;33 Suppl 3
|
|
2009 |
[Inflammatory bowel disease from
sulfasalazine to biologics]. |
Cosnes J, Seksik P.
|
Gastroenterol Clin Biol.
|
2009, Aug-Sep;33(8-9) 692-701.
|
|
2009 |
[Diagnosis of celiac disease in a
young woman]. |
Cosnes J.
|
Gastroenterol Clin Biol.
|
2009, Jun-Jul;33(6-7) 518-20.
|
|
2009 |
Can we modulate the clinical course
of inflammatory bowel diseases by our current treatment
strategies? |
Cosnes J.
|
Digestive Diseases ,.
|
2009;27(4)516-21.
|
|
2009 |
Toll-like receptor 2 is critical for induction of Reg3 beta
expression and intestinal clearance of Yersinia
pseudotuberculosis., |
Dessein R., Gironella M., Vignal C., Peyrin-Biroulet L.,
Sokol H., Secher T., Lacas-Gervais S., Gratadoux J.-J., Lafont
F., Dagorn J.-C., Ryffel B., Akira S., Langella P., N˘Òez G.,
Sirard J.-C., Iovanna J., Simonet M., Chamaillard M., |
Gut ,
|
2009, 58 6 771-6
|
|
2009 |
Endpoints for clinical trials evaluating disease
modification and structural damage in adults with Crohn's
disease. |
D'Haens GR, Fedorak R, Lémann M, Feagan BG, Kamm MA, Cosnes
J, Rutgeerts PJ, Marteau P, Travis S, Schoelmerich J, Hanauer
S, Sandborn WJ; IOIBD Membership. |
Inflamm Bowel Dis.
|
2009 Oct;15(10) 1599-604.
|
|
2009 |
Predictive factors of eczema-like eruptions among patients
without cutaneous psoriasis receiving infliximab a cohort
study of 92 patients. |
Esmailzadeh A, Yousefi P, Farhi D, Bachmeyer C, Cosnes J,
Berenbaum F, Duriez P, Aractingi S, Khosrotehrani K. |
Dermatology.
|
2009;219(3) 263-7.
|
|
2009 |
[Cutaneous manifestations
associated with chronic inflammatory bowel disease].
|
Farhi D, Cosnes J, Aractingi S,
Khosrotehrani K. |
Ann Dermatol Venereol.
|
2009 Nov;136(11) 828-33; 826-7,
834-5. |
|
2009 |
Hospital-based surveillance to estimate the burden of
rotavirus gastroenteritis among European children younger than
5 years of age. |
Forster J, Guarino A, Parez N, Moraga F, Roman E, Mory O,
Tozzi AE, de Aguileta AL, Wahn U, Graham C, Berner R, Ninan T,
Barberousse C, Meyer N, Soriano-Gabarró M; and the Rotavirus
Study Group. |
Pediatrics.
|
2009 Mar;123(3) e393-400.
|
|
2009 |
Irritable bowel syndrome is more frequent in patients
hospitalized for ischaemic colitis results of a case-control
study. |
Hervé S, Beaugerie L, Bouhnik Y, Savoye G, Colombel JF,
Dyard F, Hourmand-Ollivier I, Dao T, Vial M, Lerebours E.
|
Neurogastroenterol Motil.
|
2009 Nov;21(11) 1170-e102.
|
|
2009 |
Presentation and long-term
follow-up of refractory celiac disease comparison of type I
with type II. |
Malamut G, Afchain P, Verkarre V, Lecomte T, Amiot A,
Damotte D, Bouhnik Y, Colombel JF, Delchier JC, Allez M,
Cosnes J, Lavergne-Slove A, Meresse B, Trinquart L, Macintyre
E, Radford-Weiss I, Hermine O, Brousse N, Cerf-Bensussan N,
Cellier C. |
Gastroenterology.
|
2009 Jan;136(1) 81-90.
|
|
2009 |
The Firmicutes/Bacteroidetes ratio
of the human microbiota changes with age.,
|
Mariat D., Firmesse O., Levenez F.,
Guimarăes V., Sokol H., Doré J., Corthier G., Furet J.-P.,,
|
BMC Microbiology |
2009, 9 123
|
|
2009 |
Bacteriotherapy for inflammatory
bowel disease therapeutic tool and/or pharmacological vectors?
|
Marteau P, Sokol H, Dray X, Seksik
P. |
Gastroenterol Clin Biol.
|
2009 Jun;33 Suppl 3
|
|
2009 |
[Celiac disease].,
|
Nion-Larmurier I., Cosnes J.,
|
Gastroenterol Clin Biol.
|
2009, 33 6-7 508-17
|
|
2009 |
Papular-purpuric gloves and socks
syndrome associated with B19V infection in a 6-year-old
child., |
Parez N., Dehée A., Michel Y.,
Veinberg F., Garbarg-Chenon A., J |
Clin Virol ,
|
2009, 44 2 167-9
|
|
2009 |
Lipidomics of the red cell in
diagnosis of human disorders. |
Quinn PJ, Rainteau D, Wolf C.
|
Methods Mol Biol.
|
2009;579
|
|
2009 |
Incidence of benign upper respiratory tract infections, HSV
and HPV cutaneous infections in inflammatory bowel disease
patients treated with azathioprine., |
Seksik P., Cosnes J., Sokol H.,
Nion-Larmurier I., Gendre J.-P., Beaugerie L.,
|
Alimentary Pharmacology
and Therapeutics ,
|
2009, 29 10 1106-13
|
|
2009 |
Effects of light smoking
consumption on the clinical course of Crohn's disease.,
|
Seksik P., Nion-Larmurier I., Sokol
H., Beaugerie L., Cosnes J., |
Inflamm Bowel Dis,
|
2009, 15 5 734-41
|
|
2009 |
Epstein-Barr virus-associated lymphoproliferation awareness
in hemophagocytic syndrome complicating thiopurine treatment
for Crohn's disease., |
Serrate C., Silva-Moreno M.,
Dartigues P., Poujol-Robert A., Sokol H., Gorin N.C., Coppo
P.,, |
Inflamm Bowel Dis
|
2009, 15 10 1449-51
|
|
2009 |
Single immunoglobulin infusion can reverse hemodynamic
failure associated with severe Clostridium difficile colitis.
|
Sokol H, Maury E, Seksik P, Cosnes
J, Beaugerie L. |
Am J Gastroenterol.
|
2009 Oct;104(10) 2649-50.
|
|
2009 |
Inflammatory bowel disease and
lymphoproliferative disorders: the dust is starting to
settle., |
Sokol H., Beaugerie L.,
|
Gut ,
|
2009, 58 10 1427-36
|
|
2009 |
Plexitis as a predictive factor of
early postoperative clinical recurrence in Crohn's disease.,
|
Sokol H., Polin V., Lavergne-Slove
A., Panis Y., Treton X., Dray X., Bouhnik Y., Valleur P.,
Marteau P., |
Gut ,
|
2009, 58 9 1218-25
|
|
2009 |
Low counts of Faecalibacterium
prausnitzii in colitis microbiota., |
Sokol H., Seksik P., Furet J.P., Firmesse O.,
Nion-Larmurier I., Beaugerie L., Cosnes J., Corthier G.,
Marteau P., Doré J., |
Inflamm Bowel Dis
|
2009, 15 8 1183-9
|
|
2009 |
Gastrointestinal bleeding diagnosed
using video capsule endoscopy. Meckel's diverticulum.,
|
Sokol H., Seksik P., Wendum D.,
Bellanger J., Parc Y., Cosnes J., Beaugerie L.,,
|
Gut |
2009, 58 9 1206, 1290
|
|
2009 |
Thalidomide as a treatment for
refractory CGD colitis., |
Sokol H., Suarez F., Meatchi T.,
Malamut G., Pocidalo M.-A., Blanche S., Cellier C., Hermine O
|
Am J Gastroenterol.
|
2009, 104 4 1069
|
|
2009 |
Newborn hearing screening follow-up
factors affecting hearing aid fitting by 6 months of age.
|
Spivak L, Sokol H, Auerbach C,
Gershkovich S. |
Am J Audiol.
|
2009 Jun;18(1) 24-33.
|
|
2009 |
Galectin-4-regulated delivery of
glycoproteins to the brush border membrane of enterocyte-like
cells. |
Stechly L, Morelle W, Dessein AF, André S, Grard G, Trinel
D, Dejonghe MJ, Leteurtre E, Drobecq H, Trugnan G, Gabius HJ,
Huet G. |
Traffic. |
2009 Apr;10(4) 438-50.
|
|
2009 |
Azathioprine withdrawal in patients with Crohn's disease
maintained on prolonged remission a high risk of relapse.
|
Treton X, Bouhnik Y, Mary JY, Colombel JF, Duclos B, Soule
JC, Lerebours E, Cosnes J, Lemann M; Groupe D'Etude
Thérapeutique Des Affections Inflammatoires Du Tube Digestif
(GETAID). |
Clin Gastroenterol Hepatol.
|
2009 Jan;7(1) 80-5.
|
|
2008 |
The homeodomain derived peptide
Penetratin induces curvature of fluid membrane domains.,
|
Lamaziere A., Wolf, C., Lambert.
O., Chassaing G., Trugnan G., Ayala-Sanmartin J.,
|
PLoS ONE ,
|
2008, 3 4 e1938
|
|
2008 |
[Chronic intestinal
pseudo-obstruction and anti-Hu syndrome13 years of follow-up
without neoplasia]. |
Amiot A, Joly F, Messing B, Sokol
H, Lavergne-Slove A, Delattre JY, Bouhnik Y.
|
Gastroenterol Clin Biol.
|
2008 Jan;32(1 Pt.
|
|
2008 |
[Antibiotic-associated diarrhea].
|
Beaugerie L.
|
Rev Prat.
|
2008 Jun 15;58(11) 1207-12.
|
|
2008 |
[Microscopic colitis nosological
face-lift and research tracks]. |
Beaugerie L.
|
Gastroenterol Clin Biol.
|
2008, Aug-Sep;32(8-9) 686-8.
|
|
2008 |
Predictive factors of response to
cyclosporine in steroid-refractory ulcerative colitis.
|
Cacheux W, Seksik P, Lemann M,
Marteau P, Nion-Larmurier I, Afchain P, Daniel F, Beaugerie L,
Cosnes J. |
Am J Gastroenterol.
|
2008 Mar;103(3) 637-42.
|
|
2008 |
Incidence of autoimmune diseases in
celiac disease protective effect of the gluten-free diet.
|
Cosnes J, Cellier C, Viola S, Colombel JF, Michaud L,
Sarles J, Hugot JP, Ginies JL, Dabadie A, Mouterde O, Allez M,
Nion-Larmurier I; Groupe D'Etude et de Recherche Sur la
Maladie Coeliaque. |
Clin Gastroenterol Hepatol.
|
2008 Jul;6(7) 753-8.
|
|
2008 |
Crohn's disease phenotype,
prognosis, and long-term complications what to expect?
|
Cosnes J.
|
Acta Gastroenterol Belg.
|
2008 Jul-Sep;71(3) 303-7.
|
|
2008 |
What is the link between the use of
tobacco and IBD. |
Cosnes J.
|
Inflamm Bowel Dis
|
2008 Oct;14 Suppl 2S14-5.
|
|
2008 |
Effect of antibiotic therapy on human fecal microbiota and
the relation to the development of Clostridium difficile.
|
De La Cochetiere MF, Durand T,
Lalande V, Petit JC, Potel G, Beaugerie L.
|
Microb Ecol.
|
2008 Oct;56(3) 395-402.
|
|
2008 |
Differential solubilization of
inner plasma membrane leaflet components by Lubrol WX and
Triton X-100. |
Delaunay JL, Breton M, Trugnan G,
Maurice M. |
BBA - Biochimica et Biophysica Acta
, |
2008 Jan;1778(1) 105-12.
|
|
2008 |
Expression of nonstructural rotavirus protein NSP4 mimics
Ca2+ homeostasis changes induced by rotavirus infection in
cultured cells. |
Diaz Y, Chemello ME, Pena F, Aristimuno OC, Zambrano JL,
Rojas H, Bartoli F, Salazar L, Chwetzoff S, Sapin C, Trugnan
G, Michelangeli F, Ruiz MC. |
J Virol. |
2008 Nov;82(22) 11331-43.
|
|
2008 |
High levels of zidovudine (AZT) and its intracellular
phosphate metabolites in AZT- and AZT-lamivudine-treated
newborns of human immunodeficiency virus-infected mothers.
|
Durand-Gasselin L, Pruvost A, Dehée A, Vaudre G, Tabone MD,
Grassi J, Leverger G, Garbarg-Chenon A, Bénech H, Dollfus C.
|
Antimicrob Agents Chemother.
|
2008 Jul;52(7) 2555-63.
|
|
2008 |
Significance of erythema nodosum and pyoderma gangrenosum
in inflammatory bowel diseases a cohort study of 2402
patients. |
Farhi D, Cosnes J, Zizi N, Chosidow
O, Seksik P, Beaugerie L, Aractingi S, Khosrotehrani K.
|
Medicine.
|
2008 Sep;87(5) 281-93.
|
|
2008 |
MD-2 controls bacterial
lipopolysaccharide hyporesponsiveness in human intestinal
epithelial cells. |
Lenoir C, Sapin C, Broquet AH, Jouniaux AM, Bardin S,
Gasnereau I, Thomas G, Seksik P, Trugnan G, Masliah J,
Bachelet M. |
Life Sci.
|
2008 Feb 27;82(9-10) 519-28.
|
|
2008 |
Rotavirus gastroenteritis why to
back up the development of new vaccines?
|
Parez N. |
Comp Immunol Microbiol Infect Dis.
|
2008 Mar;31(2-3) 253-69.
|
|
2008 |
Risk factors associated with small
bowel adenocarcinoma in Crohn's disease a case-control study.
|
Piton G, Cosnes J, Monnet E, Beaugerie L, Seksik P, Savoye
G, Cadiot G, Flourie B, Capelle P, Marteau P, Lemann M,
Colombel JF, Khouri E, Bonaz B, Carbonnel F. |
Am J Gastroenterol.
|
2008 Jul;103(7) 1730-6.
|
|
2008 |
Rearrangements of rotavirus genomic segment 11 are
generated during acute infection of immunocompetent children
and do not occur at random. |
Schnepf N, Deback C, Dehee A, Gault
E, Parez N, Garbarg-Chenon A. |
J Virol. |
2008 Apr;82(7) 3689-96.
|
|
2008 |
[Severe attack of ulcerative
colitis an observation]. |
Seksik P.
|
Gastroenterol Clin Biol.
|
2008 Dec;32(12) 1038-40.
|
|
2008 |
Is there any place for alimentary probiotics, prebiotics or
synbiotics, for patients with inflammatory bowel disease?,
|
Seksik P., Dray X., Sokol H.,
Marteau P., |
Molecular Nutrition and Food Research
, |
2008, 52 8 906-12
|
|
2008 |
Disease activity and cancer risk in inflammatory bowel
disease associated with primary sclerosing cholangitis.,
|
Sokol H., Cosnes J., Chazouilleres
O., Beaugerie L., Tiret E., Poupon R., Seksik P.,,
|
World J Gastroenterology |
2008, 14 22 3497-503
|
|
2008 |
Analysis of bacterial bowel
communities of IBD patients: what has it revealed?,
|
Sokol H., Lay C., Seksik P.,
Tannock G. W., |
Inflamm Bowel Dis
|
2008, 14 6 858-67
|
|
2008 |
Faecalibacterium prausnitzii is an anti-inflammatory
commensal bacterium identified by gut microbiota analysis of
Crohn disease patients., |
Sokol H., Pigneur B., Watterlot L., Lakhdari O.,
Berm˙dez-Humar·n L. G., Gratadoux J.-J., Blugeon S.,
Bridonneau C., Furet J.-P., Corthier G., Grangette C., Vasquez
N., Pochart P., Trugnan G., Thomas G., Blottière H. M., Doré
J., Marteau P., Seksik P., Langella P.,, |
Proc Natl Acad Sci U S A.
|
2008, 105 43 16731-6
|
|
2008 |
Cost-effectiveness analysis of
vaccination against rotavirus with RIX4414 in France.
|
Standaert B, Parez N, Tehard B,
Colin X, Detournay B. |
Appl Health Econ Health Policy.
|
2008, 6(4) 199-216. doi
10.2165/00148365-
200806040-00003. |
|
2008 |
[Tolerance and efficacy of mefloquine as the first line
treatment of uncomplicated P. falciparum malaria in children].
|
Valeyre P, Favier R, Adam M, Quinet
B, Grimprel E, Parez N. |
Pathol Biol (Paris).
|
2008, Feb;56(1) 21-8.
|
|
 |
Web LBM-JM Mallet |
Equipe:
BACHELET Marie BEAUGERIE
Laurent BERBAR Tsouria BROT Loic CHEVY Françoise
CHWETZOFF Serge Pubmed
COSNES Jacques Pubmed
GARBARG-CHENON Antoine
Pubmed GRILL Jean-Pierre Pubmed
GROISARD Lucette HUMBERT Lydie LAYANI Sarah MASLIAH
Joëlle Pubmed
RAINTEAU DominiquePubmed
SEKSIK PhilippePubmed
SOKOL Harry THOMAS Ginette TRUGNAN Germain Pubmed
WOLF Claude - DUBOC Henri DUPONCHEL
Sarah LAMAZIERE Antonin
MAUBERT Marie-Anne PIGNEUR Bénédicte
QUEVRAIN Elodie SCHNURIGER
Aurélie
RAJCA Sylvie TROGNO-FARABO Dominique VU Lan
Trang
|